Phage Display in Analytical Chemistry -
Customized Affinity and Specificity.
Analytical Chemistry 80 (2008) 3082.
Phage display is a method for programming virus particles to "display" non-natural polypeptides and proteins at their surfaces. "Libraries" of virus particles can be created in which the amino acid sequence of the displayed peptide is varied and these libraries can have enormous sequence variability in the 1011 range. Such libraries can be systematically mined for sequences possessing desirable properties, such as the ability to function as receptors in chemical sensors. In this review, we discuss the prospects for advances along this coordinate.


A Covalent Virus Surface
for Mass-Based Biodetection
Analytical Chemistry 80 (2008) 933.
A self-assembed monolayer terminated with an activated NHS ester acts like fly paper to trap the equivalent 6 monolayers of the virus M13 (green filaments). Using a quartz crystal microbalance, we conclude that this "covalent virus surface" or CVS retains the ability to recognize and bind an antibody, p-Ab (red balls). Bound p-Ab can be quantitatively removed using 0.5M HCl. The CVS produces a linear calibration curve for p-Ab in the presence of flowing 140 mM PBF buffer in an experiment lasting 14 hours - a testiment to its stability.


Sub-Micron-Scale Thermocouples
with Sub-Microsecond Response Times
Nano Letters 7 (2007) 3208.
Science - Editor's Choice
Thermocouples (TCs) are the most important technology for temperature measurement. The smaller the TC, the faster it can respond to temperature changes. TCs can be prepared from electrodeposited bimetallic nanowires and these TCs show a response time of less than 1.0 microsecond.


Physical Vapor Deposition of
One-Dimensional Nanoparticle Arrays on Graphite:
Seeding the Electrodeposition of Gold Nanowires
Langmuir 23 (2007) 2372.
Physical vapor deposition (PVD) can be used to form one-dimensional arrays of gold nanoparticle "seeds". The electrodeposition of additional gold then occurs selectively at these seeds resulting in the formation of gold nanowires.


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