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| Click here to get a compiled list of links for all Rychnovsky group ACS publications for the last 10 years. Otherwise, the links for publications are listed according to project below. |
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Note to the reader: Publications are organized by project with the most recent publications first. Links to articles are provided and may be accessed where available. Single copies of the PDF files may be downloaded and printed solely for the reader's research and study |
| Prins Cyclization |
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Rhenium (VII) Catalysis of Prins Cyclization Reactions. Kwanruthai Tadpetch and Scott D. Rychnovsky. Org. Lett. 2008, ASAP |
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Formal Synthesis of (-)-Kendomycin Featuring a Prins Cyclization to
Construct the Macrocyle. Kevin B. Bahnck and Scott D. Rychnovsky. J. Am Chem.Soc. 2008, 130, 13177-13181. |
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Lewis Acid Promoted
Mukaiyama
Aldol-Prins (MAP) Cyclizations of Acetals, Ketals, and
a-Acetoxy Ethers and Orthoformates. Michael R. Gesinski, Lori Jean Van Orden, and Scott D. Rychnovsky. SynLett.. 2008, 3, 0363-0366. |
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Total Synthesis of Leucascandrolide A: A New Application of the Mukaiyama
Aldol-Prins Reaction. Lori Jean Van Orden, Brian D. Patterson, and Scott D. Rychnovsky. J. Org. Chem. 2007, 72, 5784-5793. |
| Tetrahydropyran
rings from a Mukaiyama-Michael cascade or rearrangement of dihydropyrans. Autumn Maruniak, Megan L. Bolla, and Scott D. Rychnovsky, Abstracts of Papers-224th ACS National Meeting, Boston, MA, 2007. |
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Racemization in Prins Cyclization Reactions. Ramesh Jasti and Scott D. Rychnovsky. J. Am. Chem. 2006, 128, 13640-13648. |
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Solvolysis of a Tetrahydropyranyl Mesylate: Mechanistic Implications for
the Prins Cyclization, 2-Oxonia-Cope Rearrangement, and Grob Fragmentation. Ramesh Jasti and Scott D. Rychnovsky. Org. Lett. 2006, 8, 2175-2178. |
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Tetrahdropyran Rings from a Mukaiyama-Michael Cascade Reaction. Megan L. Bolla, Brian D. Patterson, and Scott D. Rychnovsky. J. Am. Chem. Soc. 2005, 127, 16044-16045. |
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Utilization of an Oxonia-Cope Rearrangement as a Mechanistic Probe for
Prins Cyclizations. Ramesh Jasti, Christopher D. Anderson, and Scott D. Rychnovsky. J. Am. Chem. Soc. 2005, 127, 9939-9945. |
| Expanding the scope of Prins
cyclization methodology through mechanistic studies Ramesh Jasti and Scott D. Rychnovsky, Abstracts of Papers-229th ACS National Meeting, San Diego, CA, 2005. |
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Segment-Coupling Prins Cyclizations.
Scott D. Rychnovsky, Yueqing Hu, and Bruce Ellsworth. Tetrahedron Lett. 1998, 39, 7271-7274. |
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Oxonia-Cope Prins Cyclizations: A Facile Method for the Synthesis of
Tetrahydropyrans Bearing Quaternary Centers. Jackline E. Dalgard and Scott D. Rychnovsky. J. Am. Chem. Soc. 2004, 126, 15662-15663. |
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Axial-Selective Prins Cyclizations by Solvolysis of a-Bromo Ethers. Ramesh Jasti, Justin Vitale, and Scott D. Rychnovsky. J. Am. Chem. Soc. 2004, 126, 9904-9905. |
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Mukaiyama
aldol-Prins Cyclizations with Ketones. Brian Patterson and Scott D. Rychnovsky. Syn. Lett. 2004, 3, 543-545. |
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Titanium(IV)-Promoted Mukaiyama aldol-Prins Cyclizations. Brian Patterson, Shinji Marumoto, and Scott D. Rychnovsky. Org. Lett. 2003, 5, 3163-3166. |
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Synthesis of (-)-centrolobine by Prins cyclizations that
avoid racemization. Shinji Marumoto, James J. Jaber, Justin P. Vitale, and Scott D. Rychnovsky. Org. Lett. 2002, 4, 3919-3922. |
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Stereoselectivity and regioselectivity in the
segment-coupling Prins cyclization. James J. Jaber, Kazuhiko Mitsui, and Scott D. Rychnovsky. J. Org. Chem. 2001, 66, 4679-4686. |
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Role of 2-Oxonia Cope rearrangements in Prins cyclization
reactions. Scott D. Rychnovsky, Shinji Marumoto, and James J. Jaber. Org. Lett. 2001, 3, 3815-3818. |
| Steroselective Prins cyclizations in
constructing oxabicycles. Scott D. Rychnovsky, Kazuhiko Mitsui, and James J. Jaber. Abstracts of Papers-221st ACS National Meeting, Boston, MA, 2001. |
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Segment-Coupling Prins Cyclizations.
Scott D. Rychnovsky, Yueqing Hu, and Bruce Ellsworth. Tetrahedron Lett. 1998, 39, 7271-7274. |
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Prins Cyclization of 4-Allyl-1,3-Dioxanes Prepared from
1,3-Diol Synthons. A Rapid Entry into Functionalized Tetrahydropyrans. Yueqing Hu, Donald J. Skalitzky, and Scott D. Rychnovsky. Tetrahedron Lett. 1996, 37, 8679-8682. |
| Reductive Decyanation |
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Cyclization via Carbolithiation of
a-Amino
Alkyllithium Reagent Robert J. Bahde and Scott D. Rychnovsky. Org. Lett. 2008, 10, 4017-4020. |
| Construction of
fully substituted stereocenters: Alkylation followed by reductive
lithiation and cyclization of unsaturated a-aminonitriles. Robert J. Bahde and Scott D. Rychnovsky. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA. 2008. |
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A Reductive Cyclization Approach to Attenol A. Thomas E. La Cruz and Scott D. Rychnovsky. J. Org. Chem. 2007, 72, 2602-2611. |
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Diastereoselective Synthesis of the Pectenotoxin 2 Non-Anomeric AB
Spiroacetal Danielle Vellucci and Scott D. Rychnovsky. Org. Lett. 2007, 9, 711-714. |
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Stereoselectivity of Intramolecular SN' Cyclizations of Alkyllithium
Reagents on Methoxy Alkenes. Thomas E. La Cruz and Scott D. Rychnovsky. J. Org. Chem. 2006, 71, 1068-1073. |
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Reductive Spiroannulation of Nitriles with Secondary Electrophiles. Matthew D. Morin and Scott D. Rychnovsky. Org Lett. 2005, 7, 2051-2053. |
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Synthesis of the Spirofungin B Core by a Reductive Cyclization Strategy. Thomas E. La Cruz and Scott D. Rychnovsky. Org Lett. 2005, 7, 1873-1875. |
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Stereochemical course of the reductive spiroannulations of N-Boc and
N-benzyl 2-cyanopiperidines. Scott A. Wolckenhauer and Scott D. Rychnovsky. Tetrahedron. 2005, 61, 3371-3381. |
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Rational Synthesis of Contrathermodynamic Spiroacetals by Reductive
Cyclizations. Leo R. Takaoka, Alexandre J. Buckmelter, Thomas E. La Cruz and Scott D. Rychnovsky. J. Am. Chem. Soc. 2005, 127, 528-529. |
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Application of hemithio ketene acetals to the synthesis of spirocyclic
orthoesters. Thomas E. La Cruz and Scott D. Rychnovsky. Synlett. 2004, 11, 2013-2015. |
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Generation and utility of tertiary
a-aminoorganolithium reagents. Scott Wolckenhauer and Scott D. Rychnovsky. Org Lett. 2004, 6, 2745-2748. |
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Intramolecular SN2'
cyclization of an alkyllithium species onto a methoxy allyl ether is
syn selective Thomas E. La Cruz and Scott D. Rychnovsky. Chem. Commun. 2004, 2, 168-169. |
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Spiroannulation by alkylation and reductive cyclization of
nitriles. Scott D. Rychnovsky and Leo R. Takaoka. Angew. Chem. Int. Ed. 2003, 42, 818-820. |
| Investigations into the
reductive-cyclization of 2-cyano tetrahydropyrans. Leo R. Takaoka and Scott D. Rychnovsky. Abstracts of Papers, 224th ACS National Meeting, Boston, MA. 2002. |
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Use of a Conformational Radical Clock for Evaluating
Alkyllithium-Mediated Cyclization Reactions. Scott D. Rychnovsky, Takeshi Hata, Angie I. Kim and Alexandre J. Buckmelter, Org. Lett. 2001, 3, 807-810. |
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Conformational Memory in Enantioselective Radical
Reductions and a New Radical Clock Reaction. Alexandre J. Buckmelter, Angie I. Kim and Scott D. Rychnovsky. J. Am. Chem. Soc. 2000, 122, 9386-9390. |
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Non-equilibrium Radical Reductions.
Alexandre J. Buckmelter, Jay P. Powers and Scott D. Rychnovsky. J. Am. Chem. Soc. 1998, 120, 5589-5590. |
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Alkylation and Reductive Decyanation of
4-Cyano-2,2-dimethyl-1,3-dioxanes (Cyanohydrin Acetonides).
Scott D. Rychnovsky and Sonja S. Swenson. J. Org. Chem. 1997, 62, 1333-1340. |
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Conformation and Reactivity of Anomeric Radicals.
Scott D. Rychnovsky, Jay P. Powers, and Teresa J. LePage. J. Am. Chem. Soc. 1992, 114, 8375-8384. |
| Chiral Auxiliaries for Oxocarbenium Ion Reactions |
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Synthesis of Optically Pure
Arylsilylcarbinols and Their Use as Chiral Auxiliaries in Oxacarbenium Ion
Reactions. John R. Huckins and Scott D. Rychnovsky. J. Org. Chem. 2003, 68, 10135. |
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Optically pure α-(trimethylsilyl)benzyl alcohol: A
useful chiral auxiliary in oxocarbenium ion reactions. Jennifer Cossrow and Scott D. Rychnovsky. Abstracts of Papers, 226th ACS National Meeting, New York, NY. 2003. |
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Diastereoselective Additions of Nucleophiles
to α-acetoxy ethers using the α-(trimethylsilyl)benzyl auxiliary. Scott D. Rychnovsky and Jennifer Cossrow. Org. Lett. 2003, 5, 2367. |
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Optically pure α-(trimethylsilyl)benzyl alcohol: A
practical chiral auxiliary for oxocarbenium ion reactions. Jennifer Cossrow and Scott D. Rychnovsky. Org. Lett. 2002, 4, 147-150. |
| Natural Product Synthesis |
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Assignment of Absolute Configuration of SCH 351448 via Total Synthesis. Lael L. Cheung, Christopher D. Anderson, Shinji Muramoto, and Scott D. Rychnovsky, Org. Lett. 2008, 10, 3101-3104. |
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A Concise
Synthesis of ent-Cholesterol Jitendra D. Belani and Scott D. Rychnovsky, J. Org. Chem. 2008, 73, 2768-2773. |
| Substrate Chirality and Specificity of Diacylglycerol Kinases and the Multisubstrate Lipid Kinase. Epand, Richard M.; Shulga, Yulia V.; Timmons, Heath C.; Perri, Alexandra L.; Belani, Jitendra D.; Perinpanathan, Kirishanth; Johnson-McIntire, Laura Beth; Bajjalieh, Sandra; Dicu, Armela O.; Elias, Cynthia; Rychnovsky, Scott D.; Topham, Matthew K. Biochemistry. 2007, 46, 14225-14231. |
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Synthesis of the C1-C52 Fragment of Amphidinol
3, Featuring a ß-Alkoxy Alkyllithium
Addition Reaction. John R. Huckins, Javier de Vicente, and Scott D. Rychnovsky, Org. Lett. 2007, 9, 4757-4760. |
| Application of
Prins-type chemistry toward the total synthesis of SCH
351448. Lael L. Cheung, Christopher D. Anderson, Shinji Muramoto, and Scott D. Rychnovsky. Abstracts of Papers, 234th ACS National Meeting, Boston, MA. 2007. |
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Synthesis and Structure Revision of (+)-Epicalyxin F Xia Tian and Scott D. Rychnovsky, Org. Lett. 2007, 9, 4955-4958. |
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Synthesis of the C31-C67 Fragment of Amphidinol 3. Javier de Vicente, John R. Huckins, and Scott D. Rychnovsky, Angew. Chem. Int. Ed. 2006, 45, 7258-7262. |
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Total Synthesis
and Structure Reassignment of (+)-Hexacyclinol. John A. Porco, Jr., Shun Su, Xiaoguang Lei, Sujata Bardhan, and Scott D. Rychnovsky, Angew. Chem. 2006, 45, 5790-5792. |
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Predicting NMR Spectra by Computational Methods: Structural Revision of
Hexacyclinol. Scott D. Rychnovsky, Org. Lett. 2006, 8, 2895-2898. |
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Rapid
stereocontrolled assembly of the fully-substituted C-aryl glycoside of
kendomycin with a Prins cyclization: A formal synthesis. Kevin B. Bahnck and Scott D. Rychnovsky, Chem. Commun. 2006, 22, 2388-2390. |
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Synthesis and Structure Revision of Calyxin Natural Products. Xia Tian, James J. Jaber, and Scott D. Rychnovsky, J. Org. Chem. 2006, 71, 3176-3183. |
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A Mukaiyama Aldol-Prins Approach to Leucascandrolide A. Lori J. Van Orden, Brian D. Patterson, and Scott D. Rychvnovsky. Abstracts of Papers, 40th Western Regional ACS Meeting, Anaheim, CA. 2006. |
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Dual roles for
cholesterol in mammalian cells. Fang Xu, Scott D. Rychnovsky, Jitendra D. Belani, Helen H. Hobbs, Jonathan C. Cohen, and Robert B. Rawson, PNAS, 2005, 102, 14551-14556. |
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Synthesis of the C3-C19 Segment of Phorboxazole B. Justin P. Vitale, Scott A. Wolckenhauer, Nga M. Do, and Scott D. Rychnovsky, Org. Lett. 2005, 7, 3255-3258. |
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Role of chirality in peptide-induced formation of cholesterol-enriched
domains. Richard M. Epand, Scott D. Rychnovsky, Jitendra D. Belani, Raquel F. Epand, Biochemical Journal, 2005, 390, 541-548. |
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A C-Glycosidation Approach to the Central Core of Amphidinol 3: Synthesis
of the C39-C52 Fragment. Javier de Vicente, Bodo Betzemeier, and Scott D. Rychnovsky, Org. Lett. 2005, 7, 1853-1856. |
| Progress toward the
total synthesis of Lasonolide A. Gabrielle Gralla, Jackline E. Dalgard, and Scott D. Rychnovsky, Abstracts of Papers-229th ACS National Meeting, San Diego, CA, 2005. |
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A unified
approach to polyene macrolides: Synthesis of candidin and nystatin polyols. Isao Kadota, Yueqing Hu, Garrick K. Packard, and Scott D. Rychvnovsky. PNAS, 2004, 101, 11992-11995. |
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Synthetic studies toward the synthesis of lasonolide A. Jackline E. Dalgard and Scott D. Rychvnovsky. Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA. 2004. |
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Differential modulation of the antifungal activity of amphotericin B by
natural and ent-cholesterol. Rowena K. Richter, Daniel E. Mickus, Scott D. Rychnovsky, and Tadeusz F. Molinski. Bio. Med. Chem. Lett. 2004, 14, 115-118. |
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Synthesis of
Rimocidinolide methyl ester, the aglycone of (+)-Rimocidin. Garrick K. Packard, Yueqing Hu, Andrea Vescovi, and Scott D. Rychnovsky. Angew. Chem. Int. Ed. 2004, 43, 2822-2826. |
| Direct formation of
contrathermodynamic spiroketals: Synthetic studies toward the CD subunit
(C17-C28) of spongistatin 1 (alohyrtin A). Leo R. Takaoka and Scott D. Rychnovsky. Abstracts of Papers, 226th ACS National Meeting, New York, NY. 2003. |
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Progress Toward the Synthesis of SCH 351448. Christopher D. Anderson, Shinji Marumoto, and Scott D. Rychnovsky. Abstracts of Papers, 226th ACS National Meeting, New York, NY. 2003. |
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Formal Synthesis of (-)-Apicularen A. Ben Graetz and Scott D. Rychnovsky. Org. Lett. 2003, 5, 3357. |
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Unified strategy for the synthesis of (-)-elisapterosin B
and (-)-colombiasin A. Angie I. Kim and Scott D. Rychnovsky, Angew. Chem. Int. Ed. 2003, 42, 1267-1270. |
| Progress toward total synthesis of SCH
351448. Shinji Marumoto and Scott D. Rychnovsky. Abstracts of Papers, 224th ACS National Meeting, Boston, MA. 2002. |
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Total synthesis of the polyene macrolide dermostatin A. Christopher J. Sinz and Scott D. Rychnovsky. Tetrahedron. 2002, 58, 6561-6576. |
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Total synthesis of dermostatin A. Christopher J. Sinz and Scott D. Rychnovsky. Angew. Chem. Int. Ed. 2001, 40, 3224-3227. |
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Mukaiyama aldol-Prins cyclization cascade reaction: A
formal total synthesis of leucascandrolide A. David J. Kopecky and Scott D. Rychnovsky. J. Am. Chem. Soc. 2001, 123, 8420-8421. |
| Progress toward the total synthesis of dermostatin A. Scott D. Rychnovsky and Christopher J. Sinz. Abstracts of Papers-ACS 2001, 221st. |
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Stereoselective Antibody Recognition of Monolayers of Cholesterol, ent-Cholesterol,
and Epicholesterol. M. Geva, D. Izhaky, D. E. Mickus, S. D. Rychnovsky, and L. Addadi. ChemBioChem. 2001, 2, 265-271. |
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Synthesis of the C22-C26 Tetrahydropyran Segment of
Phorboxazole by a Stereoselective Prins Cyclization.
Scott D. Rychnovsky and Christian R Thomas. Org. Lett. 2000, 2, 1217-1219. |
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Total Synthesis of Filipin III.
Timothy I Richardson and Scott D. Rychnovsky. Tetrahedron. 1999, 55, 8977-96. |
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Total Synthesis of Filipin III.
Timothy I. Richardson and Scott D. Rychnovsky. J. Am. Chem. Soc. 1997, 119, 12360-12361 |
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Total Synthesis of the Polyene Macrolide Roflamycoin.
Scott D. Rychnovsky, Uday R. Khire, and Guang Yang. J. Am. Chem. Soc. 1997, 119, 2058-2059. |
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Prins Desymmetrization of a C2-Symmetric Diol: Application
to the Synthesis of 17-Deoxyroflamycoin. Scott D. Rychnovsky, Guang Yang, Yueqing Hu, and Uday R. Khire. J. Org. Chem. 1997, 62, 3022-3023. |
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Synthesis And Biological Evaluation of Non-Polyene Analogs
of Amphotericin B. Bruce N. Rogers, Michael E. Selsted and Scott D. Rychnovsky. Biorg. and Med. Chem. Lett. 1997, 7, 3177-3182. |
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Carbon-Carbon Bond Formation from Small and Medium Ring
Lactol Acetates via Radical and Oxonium-ion Intermediates. Synthesis of
(±)-Laurenan. Scott D. Rychnovsky and Vilas H. Dahanukar. J. Org. Chem. 1996, 61, 7648-7649. |
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Filipin
III-Configuration Assignment and Confirmation by Synthetic Correlation.
Timothy I. Richardson and Scott D. Rychnovsky. J. Org. Chem. 1996, 61, 4219-4231. |
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Oxo Polyene Macrolide Antibiotics.
Scott D. Rychnovsky. Chem. Rev. 1995, 95, 2021-2040. |
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Synthesis and Revised Configuration of
(+)-Combretastatin D-1. Scott D. Rychnovsky and Kooksang Hwang. Tetrahedron Lett. 1994, 35, 8927-8930. |
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Synthesis of (±)-Combretastatin D-1 and Combretastatin D-2.
Scott D. Rychnovsky and Kooksang Hwang. J. Org. Chem. 1994, 59, 5414-5418. |
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A Rapid Construction of the Roflamycoin System.
Scott D. Rychnovsky, George Griesgraber, and Jinsoo Kim. J. Am. Chem. Soc. 1994, 116, 2621-2622. |
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A Convergent Synthesis of the Polyene Macrolide
(-)-Roxaticin. Scott D. Rychnovsky and Rebecca C. Hoye. J. Am. Chem. Soc. 1994, 116, 1753-1765. |
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Convergent Synthesis of the Spiroacetal
Fragment of Milbemycin b1. Scott D. Rychnovsky and George Griesgraber. J. Chem. Soc., Chem. Commun. 1993, 291-292. |
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Synthesis of the Polyol Chain of (-)-Roxaticin.
Scott D. Rychnovsky and Cesar Rodriguez. J. Org. Chem. 1992, 57, 4793-4795. |
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Enantiomeric Cholesterol as a Probe of Ion-Channel
Structure. Daniel E. Mickus, David G. Levitt, and Scott D. Rychnovsky. J. Am. Chem. Soc. 1992, 114, 359-360. |
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Synthesis of ent-Cholesterol, the Unnatural
Enantiomer. Scott D. Rychnovsky and Daniel E. Mickus. J. Org. Chem. 1992, 57, 2732-2736. |
| Stereoselective Synthesis of the Polyene
Macrolide Antibiotics. Scott D. Rychnovsky. Acta Phamaceutica Nordica 1990, 2, 155-160. |
| Acetoxy Ether Synthesis |
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Preparation of α-acetoxy ethers by the
reductive acetylation of esters: (endo)-1-bornoxyethyl acetate (Ethanol,
O-acetoxy-, 1-(1,7,7-trimethyl-bicyclo<2.2.1>hept-2-oxy)-, (2´S)-).
David J. Kopecky and Scott D. Rychnovsky. Org. Synth., 2003, 80, 177. |
| Enantioselective
Reduction of Esters: Synthesis of Optically Active
a-Acetoxy Ethers. Scott D. Rychnovsky, Brian M. Bax. Tetrahedron Lett. 2000, 41, 3593-3596. |
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Improved
Procedure for the Reductive Acetylation of Acyclic Esters and a New
Synthesis of Ethers. David J. Kopecky and Scott D. Rychnovsky. J. Org. Chem. 2000, 65, 191-198. |
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General Synthesis of a-Acetoxy Ethers from Esters by DIBALH
Reduction and Acetylation. Vilas H. Dahanukar and Scott D. Rychnovsky. J. Org. Chem. 1996, 61, 8317-8320. |
| 1,3-Diol and 1,3-Dioxane Chemistry |
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Qualitative and Quantitative Measurements of Hydrogen Bond Mediated Scalar
Couplings in Acyclic 1,3-Diols. Nikolaus M. Loening, Carolyn E. Anderson, Wendy S. Iskenderian, Christopher D. Anderson, Scott D. Rychnovsky, Michael Barfield, Daniel J. O'Leary. Org. Lett.. 2006, 8, 5321-5323.. |
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4-Acetoxy- and 4-cyano-1,3-dioxanes in
synthesis. Christopher J. Sinz and Scott D. Rychnovsky. Topics in Curr. Chem. (Review)., 2001, 216, 51-92. |
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Synthesis, Equilibration, and Coupling of
4-Lithio-1,3-dioxanes: Synthons for syn- and anti-1,3-Diols.
Scott D. Rychnovsky, Alexandre J. Buckmelter, Vilas H. Dahanukar, and Donald J. Skalitzky. J. Org. Chem. 1999, 64, 6849-6860. |
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Anti 1,3-Diols by Addition of Dialkylzinc Reagents to
4-Acetoxy-1,3-dioxanes. Noel A. Powell and Scott D. Rychnovsky. J. Org. Chem. 1999, 64, 2026-2037. |
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Preparation of (R,R)-1,2:4,5-Diepoxypentane.
Scott D. Rychnovsky, George Griesgraber, and Jay P. Powers. Org. Synth. 1999, 77, 1-11. |
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Convergent Synthesis of a Polyol Chain with
4-Acetoxy-1,3-dioxanes Using a 1,1-Bis((trimethylsilyl)methyl)ethene
Linchpin. Scott D. Rychnovsky, Olga Fryszman, and Uday R. Khire. Tetrahedron Lett. 1999, 40, 41-44. |
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Diastereoselective Synthesis
of Polypropionates: Cationic Couplings of 4-Acetoxy-1,3-dioxanes with
Crotyl-Metal Reagents. Scott D. Rychnovsky and Christopher J. Sinz. Tetrahedron Lett. 1998, 39, 6811-6814. |
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Coupling of Alkynyl Organometallics with
4-Acetoxy-1,3-dioxanes: Synthesis of Propargylic and Allylic anti-1,3-Diols.
Noel A. Powell and Scott D. Rychnovsky. Tetrahedron Lett. 1998, 39, 3103-3106. |
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Dialkylzinc Additions to 4-Acetoxy-1,3-dioxanes: A Highly
Stereoselective Route to Protected anti-1,3-Diols.
Scott D. Rychnovsky and Noel Powell. J. Org. Chem. 1997, 62, 6460-6461. |
|
Tandem Radical Nitrile Transfer-Cyclization Reactions of
1,3-Dioxane-4-Nitriles: Synthesis of Spirocyclic Systems.
Scott D. Rychnovsky and Sonja S. Swenson. Tetrahedron 1997, 53, 16489-16502. |
| Stereoselective Radical and Cationic
Couplings in 4-Acetoxy-1,3-Dioxane Rings. Scott D. Rychnovsky and Donald J. Skalitzky. Synlett. 1995, 555-556. |
|
A Practical Preparation of
a-Alkoxylithium Reagents:
Synthesis of Syn or Anti 1,3-Diols. Scott D. Rychnovsky and Donald J. Skalitzky. J. Org. Chem., 1992, 57, 4336-4339. |
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An Iterative and Convergent Synthesis of Syn Polyols.
Scott D. Rychnovsky and George Griesgraber. J. Org. Chem. 1992, 57, 1559-1563. |
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Optically Pure 1,3-Diols from (2R,4R)- and (2S,4S)-1,2:4,5-Diepoxypentane.
Scott D. Rychnovsky, George Griesgraber, Sam Zeller, Donald J. Skalitzky. J. Org. Chem. 1991, 56, 5161-5169. |
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Stereoselective Synthesis of syn-1,3-Diol Acetonides
by Reductive Decyanation of Cyanohydrins. Scott D. Rychnovsky, Sam Zeller, Donald J. Skalitzky, and George Griesgraber. J. Org. Chem. 1990, 55, 5550-5551. |
| Stereochemistry of Alternating Polyol
Chains: 13C NMR Analysis of 1,3-Diol Acetonides. Scott D. Rychnovsky and Donald J. Skalitzky. Tetrahedron Lett. 1990, 31, 945-948. |
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A Convergent Synthesis of Polyol Chains.
Scott D. Rychnovsky. J. Org. Chem. 1989, 54, 4982-4984. |
| Nitroxide Chemistry |
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C2-Symmetric nitroxides and their potential as enantioselective oxidants. Benjamin Graetz, Scott D. Rychnovsky, Wen-Hou Lou, Patrick Farmer, and Rong Lin. Tetrahedron: Asymmetry, 2005, 16, 3584-3598. |
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Strategies for the
Generation of Molecularly Imprinted Polymeric Nitroxide Catalysts. Christopher D. Anderson, Kenneth J. Shea, and Scott D. Rychnovsky. Org. Lett., 2005, 7, 4879-4882. |
| Synthesis of chiral nitroxides for
enantioselective oxidation of alcohols. Scott D. Rychnovsky and Benjamin R. Graetz. Abstracts of Papers-ACS 2001, 221st. |
|
AM1-SM2 Calculations Model the Redox Potential of Nitroxyl
Radicals Such as TEMPO. Scott D. Rychnovsky, Rajappa Vaidyanathan, Thomas Beauchamp, Rong Lin and Patrick J. Farmer. J. Org. Chem. 1999, 64, 6745-6749. |
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TEMPO-Catalyzed Oxidations of Alcohols Using m-CPBA:
The Role of Halide Ions. |
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Synthesis of Chiral Nitroxides and an Unusual Racemization
Reaction. Scott D. Rychnovsky, Thomas Beauchamp, Rajappa Vaidyanathan, and Tricia Kwan. J. Org. Chem, 1998, 63, 6363-6374. |
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Enantioselective Oxidation of Secondary Alcohols Using a
Chiral Nitroxyl (N-Oxoammonium Salt) Catalyst.
Scott D. Rychnovsky, Terri L. McLernon, and Hemaka Rajapakse. J. Org. Chem. 1996, 61, 1194-1195. |
| 13C Acetonides |
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Direct Assigment of the Relative Configuration in Acyclic 1,3-Diols by 1H
NMR Spectroscopy. Carolyn E. Anderson, David K. Britt, Sheherbano Sangji, Daniel J. O'Leary, Christopher D. Anderson and Scott D. Rychnovsky. Org. Lett., 2005, 7, 5721-5723. |
|
Empirical model for the molar rotations of
syn-2,2-dimethyl-1,3-dioxanes. Christopher D. Anderson and Scott D. Rychnovsky. Org. Lett., 2002, 4, 3075-3078. |
|
Configurational Assignment of Polyene Macrolide Antibiotics
Using the 13-C-Acetonide Analysis.
Scott D. Rychnovsky, Bruce N. Rogers, and Timothy I. Richardson. Acc. Chem. Res. 1998, 31, 9-17. |
|
Elucidating the Origin of Conformational Energy Differences
in Substituted 1,3-Dioxanes: A Combined Theoretical and Experimental
Study. Piotr Cieplak, Allison E. Howard, Jay P. Powers, Scott D. Rychnovsky, and Peter A. Kollman. J. Org. Chem. 1996, 61, 3662-3668. |
| Relative and Absolute Configuration of
Filipin III. Scott D. Rychnovsky and Timothy I. Richardson. Angew. Chem., Int. Ed., 1995, 34, 1227-1230. |
|
Stereochemical Determination of Roflamycoin: 13C
Acetonide Analysis and Synthetic Correlation.
Scott D. Rychnovsky, George Griesgraber, and Rolf Schlegel. J. Am. Chem. Soc. 1995, 117, 197-210. |
|
The Stereochemical Assignment of Roflamycoin by 13C
Acetonide Analysis. Scott D. Rychnovsky, George Griesgraber, and Rolf Schlegel. J. Am. Chem. Soc. 1994, 116, 2623-2624. |
|
Chair and Twist-Boat Conformations of 1,3-Dioxanes:
Limitations of Molecular Mechanics Force Fields.
Scott D. Rychnovsky, Guang Yang, and Jay P. Powers. J. Org. Chem. 1993, 58, 5251-5255. |
|
Analysis of two 13C NMR Correlations for
Determining the Stereochemistry of 1,3-Diol Acetonides.
Scott D. Rychnovsky, Bruce Rogers, and Guang Yang. J. Org. Chem. 1993, 58, 3511-3515. |
|
Stereochemistry of the Macrolactins.
Scott D. Rychnovsky, Donald J. Skalitzky, Charles Pathirana, Paul R. Jensen, and William Fenical. J. Am. Chem. Soc. 1992, 114, 671-677. |
| Regiospecificity of Acetal Cleavage to an
Enol Ether Using a Carbon-13 Labeled Acetonide. Scott D. Rychnovsky and Jinsoo Kim. Tetrahedron Lett. 1991, 32, 7223-7224. |
| Other Synthetic Methods Developed in the Rychnovsky Lab |
|
Memory of chirality in the transannular cyclization of cyclodecenyl
radicals. Jackline E. Dalgard and Scott D. Rychnovsky. Org. Lett., 2004, 6, 2713-2716. |
| Memory of Chirality
in the transannular cyclization of cyclodecenyl radicals. Jackline E. Dalgard and Scott D. Rychnovsky. Abstracts of Papers, 226th ACS National Meeting, New York, NY. 2003. |
|
ß-Selective glycosylations with masked D-mycosamine
precursors. Garrick K. Packard and Scott D. Rychnovsky. Org. Lett., 2001, 3, 3393-3396. |
| Iodide
Acceleration in the Pd-Catalyzed Coupling of Aromatic 1,2-Ditriflates with
Alkynes: Synthesis of Enediynes. Noel A. Powell and Scott D. Rychnovsky. Tetrahedron Lett. 1996, 37, 7901-7904. |
|
Oxepanes from an Unusual Acetal Cleavage of
6,8-Dioxabicyclo[3.2.1]octanes. Scott D. Rychnovsky and Vilas H. Dahanukar. Tetrahedron Lett. 1996, 37, 339-342. |
|
Cascade Cyclizations of Cyclic Sulfates: An
Enantioselective Alternative to Polyepoxide Cyclizations in the Synthesis
of poly-Tetrahydrofurans. Thomas J. Beauchamp, Jay P. Powers and Scott D. Rychnovsky. J. Am. Chem. Soc. 1995, 117, 12873-12874. |
|
A Mild, Regioselective Ketal Claisen Rearrangement.
Scott D. Rychnovsky and Jennifer L. Lee. J. Org. Chem. 1995, 60, 4318-4319. |
| Reductive Lithiation of Alkyl 2-Thiopyridyl
Ethers to Generate Optically Pure a-Alkoxylithium Reagents. Scott D. Rychnovsky, Kevin Plzak, and Dacia Pickering. Tetrahedron Lett. 1994, 35, 6799-6802. |
|
Crystal and Molecular Studies of Succinimide-Lithium Salt
Complexes. Carolyn G. Choo, Scott D. Rychnovsky, and Margaret C. Etter. Chem. Mater. 1994, 6, 1200-1205. |
|
Triphenylphosphine Catalyzed Isomerizations of Enynes to (E,E,E)-Trienes:
Phenol as a Cocatalyst. Scott D. Rychnovsky and Jinsoo Kim. J. Org. Chem. 1994, 59, 2659-2660. |
| A Reverse-Phase HPLC Assay to Measure the
Interaction of Polyene Macrolide Antifungal Agents with Sterols. Bradley J. Backes and Scott D. Rychnovsky. Anal. Biochem. 1992, 205, 96-99. |
| 1-Methylcyclopropyl (MCP) Ethers as
Protecting Groups. Scott D. Rychnovsky and Jinsoo Kim. Tetrahedron Lett. 1991, 32, 7219-7222. |
| Preparation of 2-Lithiotetrahydropyrans:
Kinetic and Thermodynamic Generation of Alkyllithium Reagents. Scott D. Rychnovsky and Daniel E. Mickus. Tetrahedron Lett. 1989, 30, 3011-3014. |
| Undergraduate, Graduate, and Post-Graduate Publications by Professor Rychnovsky |
|
Approaches to the Synthesis of the Vancomycin Antibiotics.
Synthesis of Orienticin C (Bis-dechlorovancomycin) Aglycon.
D. A. Evans, J. C. Barrow, P. S. Watson, A. M. Ratz, C. J. Dinsmore, D. A. Evrard, K. M. DeVries, J. A. Ellman, S. D. Rychnovsky, and J. Lacour. J. Am. Chem. Soc. 1997, 119, 3419-3420. |
|
Two-Directional Chain Synthesis: An Application to the
Synthesis of (+)-Mycoticin A. Christopher S. Poss, Scott D. Rychnovsky, and Stuart L. Schreiber. J. Am. Chem. Soc. 1993, 115, 3360-3361. |
| A General Approach to the Asymmetric
Synthesis of Vancomycin-related Aryl Glycosides by Enolate Azidation. David A. Evans, Deborah A. Evrard, Scott D. Rychnovsky, Thomas Fruh, William G. Whittingham, and Keith M. DeVries. Tetrahedron Lett. 1992, 33, 1189-1192. |
|
Concise Total Synthesis of (+)-(9S)-Dihydroerythronolide A.
Gilbert Stork and Scott D. Rychnovsky. J. Am. Chem. Soc. 1987, 109, 1565-1567. |
|
Iterative Butenolide Construction of Polypropionate Chains.
Gilbert Stork and Scott D. Rychnovsky. J. Am. Chem. Soc. 1987, 109, 1564-1565. |
| A General Method for the Stereocontrolled
Synthesis of Polypropionate Sequences. Gilbert Stork and Scott D. Rychnovsky. Pure Appl. Chem. 1986, 58, 767-772. |
|
Free-Radical Cyclization of Bromoacetals. Use in the
Construction of Bicyclic Acetals and Lactones.
Gilbert Stork, Robert Mook, Jr., Scott A. Biller, and Scott D. Rychnovsky. J. Am. Chem. Soc. 1983, 105, 3741-3742. |
|
Stereocontrolled Synthesis of Cis-2,5-Disubstituted
Tetrahydrofurans and cis- and trans-Linalyl Oxides.
Scott D. Rychnovsky and Paul A. Bartlett . J. Am. Chem. Soc. 1981, 103, 3963-3964. |
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